Ron Perlman wedded his significant other, adornments fashioner Opal, on February 14, 1981. They have two youngsters: girl Blake Amanda Perlman (brought into the world 1984) and child Brandon Avery Perlman (brought into the world 1990). His child produces electronic music under the stage name Delroy Edwards. They isolated in May 2019 and Perlman later petitioned for legal separation. 

Perlman depicted himself as a long lasting Democrat in November 2016. 

Perlman has been a vocal pundit of U.S. President Donald Trump. On October 29, 2016 Perlman tweeted "Ya hear that donnie? Warped as a muthafucka!" regarding another tweet about the Hillary Clinton email contention. 

Accordingly, on June 25, 2018 Perlman tweeted asserting that he peed on his hand preceding shaking Harvey Weinstein's hand trailed by the message "I consider that each time lil donnie opens up his KFC." These tweets have roused the "Lil Donnie" image wherein web clients photoshop imaginary tweets of Perlman doing disturbing and foolish acts so as to pay back "Lil Donnie." 

On November 9, 2016, Perlman declared by means of Facebook his aim to run for U.S. President in the 2020 political race yet dropped out in January 2019, rather embracing Kamala Harris.[